Lichen sclerosus is a skin disorder of unknown prevalence affecting both men and women, and several studies have established HLA associations in women with this disease. Autoimmune disease associations in the form of a personal and/or family history of autoimmune disease have also been shown to be r
Survey of genital lichen sclerosus in women and men
β Scribed by M. Hagedorn; B. Buxmeyer; Y. Schmitt; T. Bauknecht
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 136 KB
- Volume
- 266
- Category
- Article
- ISSN
- 0003-9128
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An 83-year-old woman presented with a vulval mass. Radical vulvectomy was performed and histology showed a unique mixed picture of spindle, pseudoglandular and classical squamous cell carcinoma arising in vulval lichen sclerosus.
## Background: Topical corticosteroids have become the treatment of choice for genital lichen sclerosus (ls) and are believed to be required for long-term relief of symptoms. ## Objective: To compare vulval ls that had been treated with topical corticosteroids, vulval ls that had not received top
## Abstract Squamous cell carcinoma (SCC) of the vulva is a heterogeneous disease, associated or not with vulvar lichen sclerosus (LS). The precursor role of LS in vulvar cancer is unclear. We studied the epigenetic alterations of __RASSF1A__, __RASSF2A__, __p16__, __TSPβ1__ and __MGMT__ genes in v