Surprising performance of alginate beads for the release of low-molecular-weight drugs
β Scribed by Magdy M. Elnashar; Mohamed A. Yassin; Abou El-Fetouh Abdel Moneim; Elsayed M. Abdel Bary
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 304 KB
- Volume
- 116
- Category
- Article
- ISSN
- 0021-8995
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## Abstract Novel polymeric sodium alginate (NaβAlg) interpenetrating network (IPN) beads have been prepared by crosslinking NaβAlg blend with gelatin (GE) or egg albumin (EA) using glutaraldehyde (GA) as the crosslinking agent. These beads were used for the controlled release of chlorpyrifos. The
Capillary electrophoresis frontal analysis was applied to 12 low molecular weight compounds including 8 drug substances displaying a range of different properties with respect to binding affinity, binding location, structure, lipophilicity, charge at physiological pH, and electrophoretic mobility. I