Drug–Cyclodextrin Association Constants
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Angelina Angelova; Catherine Ringard-Lefebvre; Adam Baszkin
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Article
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1999
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Elsevier Science
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English
⚖ 76 KB
The complexation reaction between the amphiphilic peptide antibiotic polymyxin B and naturally occurring cyclodextrins, used as potential drug carriers, was quantitatively evaluated from surface tension measurements at various drug concentrations. The association constant, Ka, of polymyxin B:beta-cy