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Drug–Cyclodextrin Association Constants Determined by Surface Tension and Surface Pressure Measurements: I. Host–Guest Complexation of Water Soluble Drugs by Cyclodextrins: Polymyxin B–β Cyclodextrin System

✍ Scribed by Angelina Angelova; Catherine Ringard-Lefebvre; Adam Baszkin

Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 76 KB
Volume: 212
Category: Article
ISSN: 0021-9797
DOI: 10.1006/jcis.1999.6088

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✦ Synopsis

The complexation reaction between the amphiphilic peptide antibiotic polymyxin B and naturally occurring cyclodextrins, used as potential drug carriers, was quantitatively evaluated from surface tension measurements at various drug concentrations. The association constant, Ka, of polymyxin B:beta-cyclodextrin inclusion complex formation of 1:1 stoichiometry was determined from the change in the drug interfacial activity upon the addition of beta-cyclodextrin at the excess solution concentration (10(-3) M). The obtained Ka value is discussed in terms of molecular matching of the host cyclodextrin cavity and the guest drug molecule. Copyright 1999 Academic Press.

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Drug–Cyclodextrin Association Constants

Drug–Cyclodextrin Association Constants Determined by Surface Tension and Surface Pressure Measurements: II. Sequestration of Water Insoluble Drugs from the Air–Water Interface: Retinol–β Cyclodextrin System

✍ Angelina Angelova; Catherine Ringard-Lefebvre; Adam Baszkin 📂 Article 📅 1999 🏛 Elsevier Science 🌐 English ⚖ 138 KB

The compression of water-insoluble drug monolayers spread on the aqueous subphase containing cyclodextrins (CD) led to a shift of surface pressure (pi)-area (A) isotherms toward smaller molecular areas with respect to the pi-A isotherms on the pure water subphase. The displacement of the compression