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Surface Modification of Hydroxyapatite Nanoparticles with Thermal-Responsive PNIPAM by ATRP

✍ Scribed by Junchao Wei; Pan He; Aixue Liu; Xuesi Chen; Xianhong Wang; Xiabin Jing

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
591 KB
Volume
9
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

Hydroxyapatite (HA) nanoparticles grafted by poly(N‐isopropylacrylamide) (PNIPAM) brushes (PNIPAM‐g‐HA) have been synthesized by the surface‐initiated atom transfer radical polymerization (ATRP) of N‐isopropylacrylamide (NIPAM). The surface grafting amount of PNIPAM ranges from 15.5% to 46.4%. PNIPAM‐g‐HA has been characterized by FT‐IR spectroscopy, thermal gravimetric analysis, X‐ray diffraction, and scanning electron microscopy (SEM). The UV transmittance spectra and the particle size analysis of PNIPAM‐g‐HA in aqueous solution demonstrates that the PNIPAM‐g‐HA possess reversible thermal stimuli responsive properties. An in vitro bioactivity assessment indicates that PNIPAM‐g‐HA can induce the mineralization of Ca^2+^ and HPO and possesses an excellent bioactivity. The cell culture results show that the cells adhered to the surface of PNIPAM‐g‐HA grow better than on HA, and the area of the cells on the surface of PNIPAM‐g‐HA is much greater than for HA, which proves that the PNIPAM‐g‐HA has a better biocompatibility than HA.

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