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Surface Functionalized Cationic Lipid-DNA Complexes for Gene Delivery: PEGylated Lamellar Complexes Exhibit Distinct DNA-DNA Interaction Regimes

✍ Scribed by Martin-Herranz, Ana; Ahmad, Ayesha; Evans, Heather M.; Ewert, Kai; Schulze, Uwe; Safinya, Cyrus R.


Book ID
118515986
Publisher
Biophysical Society
Year
2004
Tongue
English
Weight
418 KB
Volume
86
Category
Article
ISSN
0006-3495

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## Abstract ## Background Gene carriers based on lipids or polymers—rather than on engineered viruses—constitute the latest technique for delivering genes into cells for gene therapy. Cationic liposome–DNA (CL‐DNA) complexes have emerged as leading nonviral vectors in worldwide gene therapy clinic