𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Surface active properties of viscosin: a peptidolipid antibiotic

✍ Scribed by Thomas R. Neu; Thomas Härtner; Karl Poralla

Publisher
Springer
Year
1990
Tongue
English
Weight
326 KB
Volume
32
Category
Article
ISSN
1432-0614

No coin nor oath required. For personal study only.

✦ Synopsis

A surfactant was purified from a Pseudomonas fluorescens strain isolated while screening for bacteria with hydrophobic surfaces. The surfactant was separated from the isolated extract by the use of thin-layer chromatography and detected as a ninhydrin-negative, 4,4'-tetramethyldiamino-diphenylmethane-positive spot. HPLC of the purified substance resulted in one single peak. The amino acid composition was identical to viscosin, a peptidolipid. Fast-atom bombardment mass spectrometry showed a mass peak at m/z 1126. Surface tension measurements revealed a value of 26.5 m N / m and a critical micelle concentration of 0.15 mg/ml. * This paper is dedicated to Professor Hans Zahner on the occasion of his 60th birthday

📜 SIMILAR VOLUMES

Solid-phase synthesis of viscosin, a cyc
Solid-phase synthesis of viscosin, a cyclic depsipeptide with antibacterial and antiviral properties
✍ Terrence R. Burke Jr.; Martha Knight; Bhaskar Chandrasekhar; James A. Ferretti 📂 Article 📅 1989 🏛 Elsevier Science 🌐 French ⚖ 291 KB

Viscosin, a cyclic depsipeptide (containing a peptide lactone) has been prepared by solid-phase chemistry using an Fmoc-protocol starting with an acid sensitive resin. Cyclization with the activating agent BOP-Cl gave a product which was indistinguishable from natural viscosin thereby supporting the