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Suppressive effect of COX2 inhibitor on the progression of adipose inflammation in high-fat-induced obese rats

✍ Scribed by P.-S. Hsieh; K.-C. Lu; C.-F. Chiang; C.-H. Chen

Book ID
108713915
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
246 KB
Volume
40
Category
Article
ISSN
0014-2972

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## Abstract The effect of obesity induced by a high‐fat diet on the pharmacokinetics (PK) of nelfinavir (NFV) was investigated, focusing on the change of distribution and elimination caused by dyslipidemia and hepatic steatosis. The plasma unbound fraction (__f__~u~) of NFV in obese rats (0.61Β±0.0