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Suppression of topoisomerase IIα expression and function in human cells decreases chromosomal radiosensitivity

✍ Scribed by Samantha Y.A. Terry; Andrew C. Riches; Peter E. Bryant

Book ID
113809275
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
472 KB
Volume
663
Category
Article
ISSN
0027-5107

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Cellular resistance to etoposide has been correlated both with reduced levels and an aberrant cytoplasmic accumulation of the drug's target, topoisomerase II␣ (topo II␣). It is not known, however, whether a cytoplasmic pool of topo II␣ is sufficient to confer drug resistance on cultured mammalian ce