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Suppression of T cell functions by hydroxamic acid-based histone deacetylase inhibitors

โœ Scribed by Kim, Young Hoon; Lee, Jae Kwon


Book ID
113100947
Publisher
Springer
Year
2012
Tongue
English
Weight
756 KB
Volume
35
Category
Article
ISSN
0253-6269

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## Abstract Acetylation of histones leads to conformational changes of DNA. We have previously shown that the histone deacetylase (HDAC) inhibitor, suberoylanilide hydroxamic acid (SAHA), induced cell cycle arrest, differentiation, and apoptosis. In addition to their antitumor effects as single age