Sequence-specific potentiation of topois
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Douglas C. Marchion; Elona Bicaku; Adil I. Daud; Victoria Richon; Daniel M. Sull
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Article
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2004
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John Wiley and Sons
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English
โ 469 KB
๐ 1 views
## Abstract Acetylation of histones leads to conformational changes of DNA. We have previously shown that the histone deacetylase (HDAC) inhibitor, suberoylanilide hydroxamic acid (SAHA), induced cell cycle arrest, differentiation, and apoptosis. In addition to their antitumor effects as single age