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Suppression of proline-directed protein kinase FA expression potentiates erythroid differentiation of human myeloid leukemia cells

✍ Scribed by Chih-Ping Hsu; Chuan-Ching Yang; Shiaw-Der Yang


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
167 KB
Volume
89
Category
Article
ISSN
0008-543X

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Suppression of proline-directed protein
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Initial studies revealed that proline-directed protein kinase F A (PDPK F A ) was overexpressed in various cancerous tissues relative to normal controls. However, the functional role of overexpressed PDPK F A in cancer remains to be established. In this report, we explore the potential role of PDPK

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## BACKGROUND. Previously, the authors reported that specific antisense suppression of overexpressed proline-directed protein kinase (PDPK) F A enhances the chemosensitivity of various clinical anticancer drugs up to ΟΎ 100-fold in human prostate carcinoma cells, suggesting an association of PDPK F