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Suppression of pancreatitis-related allodynia/hyperalgesia by proteinase-activated receptor-2 in mice

✍ Scribed by Atsufumi Kawabata; Maho Matsunami; Masahiro Tsutsumi; Tsuyoshi Ishiki; Osamu Fukushima; Fumiko Sekiguchi; Naoyuki Kawao; Takeshi Minami; Toru Kanke; Naohiro Saito

Book ID: 110009098
Publisher: Nature Publishing Group
Year: 2009
Tongue: English
Weight: 212 KB
Volume: 148
Category: Article
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0706708

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## Abstract Proteinase‐activated receptor‐2 (PAR‐2), which is a G protein‐coupled receptor, is activated in inflammatory processes and cell proliferation. We previously demonstrated that an anti‐PAR‐2 antibody suppresses proliferation of human pancreatic cells __in vitro__. However, there have been