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Proteinase-activated receptor-2 (PAR-2): regulation of salivary and pancreatic exocrine secretion in vivo in rats and mice

✍ Scribed by Atsufumi Kawabata; Hiroyuki Nishikawa; Ryotaro Kuroda; Kenzo Kawai; Morley D Hollenberg


Book ID
110004953
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
183 KB
Volume
129
Category
Article
ISSN
0007-1188

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## Abstract ## Objective Serine proteinases activate the G protein–coupled receptor, proteinase‐activated receptor 2 (PAR‐2), via cleavage and exposure of a tethered ligand. PAR‐2 is known to exert proinflammatory actions in a murine model of arthritis, since PAR‐2–deficient mice exhibit strikingl