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Suppression of Oxidative Stress by -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

✍ Scribed by Shimazu, T.; Hirschey, M. D.; Newman, J.; He, W.; Shirakawa, K.; Le Moan, N.; Grueter, C. A.; Lim, H.; Saunders, L. R.; Stevens, R. D.; Newgard, C. B.; Farese, R. V.; de Cabo, R.; Ulrich, S.; Akassoglou, K.; Verdin, E.

Book ID
118118646
Publisher
American Association for the Advancement of Science
Year
2012
Tongue
English
Weight
765 KB
Volume
339
Category
Article
ISSN
0036-8075

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## Abstract In cells with an altered __p53__ gene, the expression of p21^__WAF1__/__CIP1__^, a potent inhibitor of cyclin‐dependent kinases, can be induced by histone deacetylase (HDAC) inhibitors via a __p53__‐independent pathway, which may play a critical role in arrest of cell growth. Accordingl