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Suppression of MYC by high expression of NMYC in human neuroblastoma cells

✍ Scribed by S. Breit; M. Schwab

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
854 KB
Volume
24
Category
Article
ISSN
0360-4012

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✦ Synopsis

Members of the MYC gene family, including MYC, NMYC, and LYMC, have been found amplified and expressed at high level in various human cancers. We have analysed the expression of two members of the MYC gene family, NMYC and MYC, in human and murine neuroblastoma cells. Whenever NMYC and MYC are co-expressed, MYC expression predominates. Cells carrying high expression of NMYC as result of amplification lack MYC expression. The same is true for neuroblastoma cells in which expression of a single-copy NMYC is upregulated or into which a vector forcing high expression of an exogenous NMYC had been introduced by transfection. Our studies indicate a regulatory interaction between MYC and NMYC in neuroblastoma cells.

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