Suppression of mitogen-activated protein kinase phosphatase-1 (MKP-1) by heparin in vascular smooth muscle cells
β Scribed by Yong Zhao; Weiqun Xiao; Douglas M. Templeton
- Book ID
- 113993625
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 308 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0006-2952
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## Abstract The mitogenβactivated protein kinase phosphataseβ1, MKPβ1 (CL100) is involved in inactivation of MAPβkinase pathways, regulation of stressβresponses and suppression of apoptosis. We investigated expression of MKPβ1 in 90 cases of primary ovarian tumors, 11 normal ovaries as well as 4 ov
## Abstract The ability of heparin to block proliferation of vascular smooth muscle cells has been well documented. It is clear that heparin treatment can decrease the level of ERK activity in vascular smooth muscle cells that are sensitive to heparin. In this study, the mechanism by which heparin