## Abstract Elevated 3โhydroxyโ3โmethylglutaryl coenzyme A (HMGโCoA) reductase expression supports synthesis of prenyl pyrophosphate intermediates required for tumor growth. In this study, the copy number of HMGโCoA reductase mRNA was determined in solid tumor and leukemic cell lines using competit
Suppression of lymphoid cell function in vitro by inhibition of 3-hydroxy-3-methylglutaryl coenzyme a reductase by lovastatin
โ Scribed by J.Lynn Cutts; A.D. Bankhurst
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 536 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0192-0561
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
ative ultracentrifugation as described by Havel et al. 16 using a Sor-Pa หhlsson Foundation, the Research Foundation of Malmo ยจUniversity Hospital, the Ernold vall Oil Turbine Drive 75 ultracentrifuge (Sorvall Products, Lundstro ยจm Foundation, and the Crafoord Foundation. Wilmington, DE). A narrow d
Elevation of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase, EC 1.1.1.34) activity by glucocorticoids was shown to be dependent on the concentration of hormone in the medium over a range of 5 X
Although plasma lipoproteins have been demonstrated to have a major role in regulating cholesterol biosynthesis in extraneural cells, no data concerning such regulation are available for developing brain, when cholesterol synthesis is especially active. Glial primary cultures derived from neonatal r
When the disulfide of 2-mercaptoethanol (ESSE) is added to the medium of cultured Chinese hamster ovary (CHO) cells, a time and concentration dependent release of 2-mercaptoethanol to the medium is observed. The reduction of ESSE to 2-mercaptoethanol by cells is a saturable process, the rate being a
## Abstract The specific activity of HMGโCoA reductase, the major rateโlimiting enzyme in the sterol biosynthetic pathway, declined linearly with increasing cell density in four different lines of mammalian cell cultures. As expected, this caused the rates of sterol synthesis from [^14^C]acetate to