## Abstract The specific activity of HMG‐CoA reductase, the major rate‐limiting enzyme in the sterol biosynthetic pathway, declined linearly with increasing cell density in four different lines of mammalian cell cultures. As expected, this caused the rates of sterol synthesis from [^14^C]acetate to
✦ LIBER ✦
Elevation of HeLa cell 3-hydroxy-3-methylglutaryl coenzyme a reductase activity by glucocorticoids: Possible relationship to the cell cycle
✍ Scribed by Dr. Webster K. Cavenee; George Melnykovych
- Publisher
- John Wiley and Sons
- Year
- 1979
- Tongue
- English
- Weight
- 968 KB
- Volume
- 98
- Category
- Article
- ISSN
- 0021-9541
No coin nor oath required. For personal study only.
✦ Synopsis
Elevation of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase, EC 1.1.1.34) activity by glucocorticoids was shown to be dependent on the concentration of hormone in the medium over a range of 5 X
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ative ultracentrifugation as described by Havel et al. 16 using a Sor-Pa ˚hlsson Foundation, the Research Foundation of Malmo ¨University Hospital, the Ernold vall Oil Turbine Drive 75 ultracentrifuge (Sorvall Products, Lundstro ¨m Foundation, and the Crafoord Foundation. Wilmington, DE). A narrow d