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Suppression of in vivo bile acid synthesis, but not of in vitro cholesterol 7α-hydroxylase expression, by biliary obstruction in humans

✍ Scribed by M. Bertolotti; L. Carulli; M. Concari; P. Martella; P. Loria; E. Tagliafico; E. De Fabiani; C. Amorotti; N. Carulli

Book ID
119526131
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
164 KB
Volume
32
Category
Article
ISSN
0168-8278

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Bile acids exert negative feedback contr
Bile acids exert negative feedback control on bile acid synthesis in cultured pig hepatocytes by suppression of cholesterol 7α-hydroxylase activity
✍ Jaap Kwekkeboom; Dr. Hans M. G. Princen; Eline M. van Voorthuizen; Dr. Herman Ja 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 847 KB

Feedback regulation of bile acid synthesis by its end products was studied in cultured hepatocytes of young weaned pigs. We previously showed that conversion of exogenous ["Cl cholesterol into bile acids was suppressed by addition of bile acids to the culture medium. In the present study, the effec