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Suppression of gonadotrophin secretion does not reverse premature ovarian failure

โœ Scribed by W. L. LEDGER; E. J. THOMAS; D. BROWNING; E. A. LENTON; I. D. COOKE


Book ID
111154452
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
271 KB
Volume
96
Category
Article
ISSN
1470-0328

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X chromosome inactivation does not defin
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## Abstract Since only 20% of female fragile X premutation carriers develop premature ovarian failure (POF, i.e., amenorrhea before age of 40 years), and since X chromosome inactivation (XCI) determines the phenotypic severity of full mutation women, we reasoned that the development of POF in fragi