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Suppression of ethanol tolerance and dependence in rats treated with DSP-4, a noradrenergic neurotoxin

✍ Scribed by Trzaskowska, Ewa; Puciłowski, Olgierd; Dyr, Wanda; Kostowski, Wojciech; Hauptmann, Mirosława


Book ID
123141873
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
321 KB
Volume
18
Category
Article
ISSN
0376-8716

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✍ Edward Majchrowicz; Walter A. Hunt 📂 Article 📅 1976 🏛 Springer 🌐 English ⚖ 576 KB

Rats were treated by intragastric intubation of a 20 % ethanol solution in doses of 9-15 g/kg in 3-5 fractions for 1-7 days. Both tolerance and physical dependence were demonstrated after this treatment with the maximum tolerable doses to only a few days. Tolerance was assessed by signs of severity