Neuroprotection by R(−)-deprenyl and N-2-hexyl-N-methylpropargylamine on DSP-4, a neurotoxin, induced degeneration of noradrenergic neurons in the rat locus coeruleus

Immunohistochemical evidence of neuropro

Immunohistochemical evidence of neuroprotection by R(−)-deprenyl and N-(2-hexyl)-N-methylpropargylamine on DSP-4-induced degeneration of rat brain noradrenergic axons and terminals

✍ X. Zhang; D.-M. Zuo; B.A. Davis; A.A. Boulton; P.H. Yu 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 964 KB

## DSP-4 [N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine] is a potent neurotoxin highly selective to the locus coeruleus noradrenaline (NA) system. Previous biochemical studies have shown that the monoamine oxidase-B (MAO-B) inhibitors, R( -)-deprenyl and are able to prevent DSP-4 induced NA deplet