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Suppression of Epstein-Barr nuclear antigen 1 (EBNA1) by RNA interference inhibits proliferation of EBV-positive Burkitt’s lymphoma cells

✍ Scribed by Mei Hong; Yoshihiro Murai; Tomohiko Kutsuna; Hiroyuki Takahashi; Kazuhiro Nomoto; Chun-Mei Cheng; Shin Ishizawa; Qing-Li Zhao; Ryohei Ogawa; Brian V. Harmon; Koichi Tsuneyama; Yasuo Takano


Publisher
Springer-Verlag
Year
2005
Tongue
English
Weight
438 KB
Volume
132
Category
Article
ISSN
1432-1335

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Two human Burkitt's lymphoma cell lines (HBL-4 and HBL-5) were established individually from two patients with small noncleaved cell lymphoma (Burkitt's type). The HBL-4 cell line is Epstein-Barr virus (EBV)-negative, and the HBL-5 cell line is EBV-positive. Cytogenetically, both cell lines had the