Suppression of antitumor immunity by macrophages in spleens of mice bearing a large MOPC-315 tumor
β Scribed by Qing-Wei Ye; Margalit B. Mokyr; Joseph M. Pyle; Sheldon Dray
- Publisher
- Springer-Verlag
- Year
- 1984
- Tongue
- English
- Weight
- 928 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0340-7004
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π SIMILAR VOLUMES
Administration of a low dose of L-PAM (0.75 mg/kg) to mice bearing a large SC MOPC-315 tumor and extensive metastases led to the development of augmented antitumor immune potential in their hitherto immunosuppressed spleen cells. Such drug-induced potentiation of antitumor immune responsiveness appe
Some T cell-dependent immune parameters were examined in mice bearing a large MOPC-315 plasmacytoma before and after treatment with a low dose (15 mg/kg) of CY. Prior to CY therapy, spleen cells from mice bearing a large MOPC-315 tumor were depressed in their ability to generate an in vitro cytotoxi
## Abstract Spleen cells from BALB/c mice that are in the process of eradicating a large MOPCβ315 tumor following lowβdose LβPAM therapy (LβPAM TuB spleen cells) were previously shown to be capable of bringing about the complete regression of a large (15 to 20 mm) s.c. MOPCβ315 tumor in a substanti
## Abstract The frequency of rosetteβforming cells (RFC) in spleens of mice immunized with sheep red blood cells (SRBC) was significantly reduced by pretreatment with preparations obtained from tumor extracts. This effect was not produced by preparations obtained by similar methods from normal tiss
## Abstract The evolution of the specific cellβmediated immune status was studied in C57BL/6 mice bearing a chemically induced syngeneic sarcoma, the TBL CL2 tumor. Peritoneal cells (PC) as the source of immunocompetent cells were repeatedly harvested from the same groups of mice checked in the in