Administration of a low dose of L-PAM (0.75 mg/kg) to mice bearing a large SC MOPC-315 tumor and extensive metastases led to the development of augmented antitumor immune potential in their hitherto immunosuppressed spleen cells. Such drug-induced potentiation of antitumor immune responsiveness appe
Cyclophosphamide-mediated enhancement of antitumor immune potential of immunosuppressed spleen cells from mice bearing a large MOPC-315 tumor
โ Scribed by Margalit B. Mokyr; Michael Colvin; Sheldon Dray
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 953 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0192-0561
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๐ SIMILAR VOLUMES
Some T cell-dependent immune parameters were examined in mice bearing a large MOPC-315 plasmacytoma before and after treatment with a low dose (15 mg/kg) of CY. Prior to CY therapy, spleen cells from mice bearing a large MOPC-315 tumor were depressed in their ability to generate an in vitro cytotoxi
## Abstract Spleen cells from BALB/c mice that are in the process of eradicating a large MOPCโ315 tumor following lowโdose LโPAM therapy (LโPAM TuB spleen cells) were previously shown to be capable of bringing about the complete regression of a large (15 to 20 mm) s.c. MOPCโ315 tumor in a substanti