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Suppression by apigenin of peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats

✍ Scribed by Masaharu Tatsuta; Hiroyasu Iishi; Miyoko Baba; Hiroyuki Yano; Kohei Murata; Mutsuko Mukai; Hitoshi Akedo


Book ID
110319286
Publisher
Springer
Year
2000
Tongue
English
Weight
84 KB
Volume
18
Category
Article
ISSN
0262-0898

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Genistein attenuates peritoneal metastas
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The effects of the soybean isoflavonoid genistein on the development of bombesin-enhanced peritoneal metastasis from intestinal adenocarcinomas induced by azoxymethane (AOM) were investigated in male inbred Wistar rats. From the beginning of the experiment, rats were given 10 weekly s.c. injections

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## Abstract The effect of cyclic phosphatidic acid, a unique analogue of lysophosphatidic acid, on the induction of bombesin‐enhanced peritoneal metastases from intestinal adenocarcinomas induced by azoxymethane was investigated in male Wistar rats. Rats were given 10 weekly injections of azoxymeth

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MATERIAL AND METHODS ## Animals Sixty male Wistar rats were received from SLC (Shizuoka, Japan) at 45 days of age and maintained in isolation for 10 days. The animals were housed in suspended cages with wire-mesh bottoms in animal quarters at controlled tempera-3To whom correspondence and reprint