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Supplemental iron exacerbates aminoglycoside ototoxicity in vivo

✍ Scribed by Brendan J Conlon; David W Smith

Book ID: 117534912
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 296 KB
Volume: 115
Category: Article
ISSN: 0378-5955
DOI: 10.1016/s0378-5955(97)00171-8

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## Abstract We constructed a powerful artificial cytoprotective protein, FNK, from an antiapoptotic member of the BCL‐2 family, Bcl‐x~L~. To test the efficacy of FNK in protecting cochlear hair cells (HCs) from aminoglycoside‐induced cell death in vivo, we fused FNK with protein transduction domain