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Superinduction of COX-2 mRNA by cycloheximide and interleukin-1β involves increased transcription and correlates with increased NF-κB and JNK activation

✍ Scribed by Robert Newton; David A. Stevens; Lorraine A. Hart; Mark Lindsay; Ian M. Adcock; Peter J. Barnes


Book ID
117108444
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
542 KB
Volume
418
Category
Article
ISSN
0014-5793

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Superinduction of IL-6 by cycloheximide
✍ Dan D. Hershko; Bruce W. Robb; Curtis J. Wray; Guan-ju Luo; Per-Olof Hasselgren 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 175 KB

## Abstract Protein synthesis inhibitors paradoxically increase the expression of early‐gene products, including various cytokines, through a process known as superinduction. Superinduction is cell‐specific and the mechanisms involved are not fully understood but are usually attributed to decreased