Supercritical fluid chromatography and steady-state recycling: Phase appropriate technologies for the resolutions of pharmaceutical intermediates in the early drug development stage

The application of preparative batch HPL

The application of preparative batch HPLC, supercritical fluid chromatography, steady-state recycling, and simulated moving bed for the resolution of a racemic pharmaceutical intermediate

✍ Tony Q. Yan; Carlos Orihuela; David Swanson 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 328 KB 👁 1 views

## Abstract This article discusses the chromatographic resolution of a racemic pharmaceutical intermediate. Preparative batch high performance liquid chromatography (HPLC), supercritical fluid chromatography (SFC), steady‐state recycling (SSR), and simulated moving bed (SMB) were used to resolve a