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SUMOylation can regulate the activity of ETS-like transcription factor 4

โœ Scribed by Sanna Kaikkonen; Harri Makkonen; Miia Rytinki; Jorma J. Palvimo


Book ID
116272600
Publisher
Elsevier
Year
2010
Tongue
English
Weight
705 KB
Volume
1799
Category
Article
ISSN
1874-9399

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Overexpression of the HER2/Neu receptor is correlated to a poor prognosis in tumor patients and leads to stimulation of mitogen-activated protein kinase (MAPK) signaling pathways, which in turn activate transcription factors, such as the ETS protein ER81. Here, we have analyzed whether, on the other