SULT1A1 polymorphism and esophageal cancer in males

✍ Scribed by Ming-Tsang Wu; Yi-Ting Wang; Chi-Kung Ho; Deng-Chyang Wu; Yung-Chie Lee; Hon-Ki Hsu; Ein-Long Kao; Jang-Ming Lee

• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: French
• Weight: 98 KB
• Volume: 103
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.10805

✦ Synopsis

Abstract

Sulfotransferase (SULT) 1A1 detoxifies and bioactivates a broad spectrum of substrates including xenobiotics. It has been suggested that the SULT1A1 his (histidine) allele, which is caused by a his for arg (arginine) substitution due to a G→A transition at codon 213, carries a significantly higher risk for women to develop breast cancer. We investigated the association between the SULT1A1 arg/his genotype and esophageal cancer in men, 187 cases of esophageal squamous cell carcinoma and 308 controls from 3 medical centers in Taiwan. Cigarette smoking, areca chewing and alcohol consumption were the major risks for developing esophageal cancer. The frequencies of arg/his in cases and controls were 27.8% (52/187) and 11.0% (34/308), respectively (p < 0.0001). No subjects carried his/his. After adjusting for substance use and other covariates, individuals with arg/his had a 3.53‐fold higher risk (95% CI = 2.12–5.87) of developing esophageal cancer than those with arg/arg. Unexpectedly, this positive association was found to be even stronger (adjusted OR = 4.04–4.80) among non‐smokers, non‐drinkers or non‐chewers. Our findings suggest that the SULT1A1 his^213^ allele is important in the development of esophageal cancer in men. © 2002 Wiley‐Liss, Inc.