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Sulphinpyrazone prevents in vivo the inhibitory effect of aspirin on rat platelet cyclo-oxygenase activity

โœ Scribed by Grazyna Rajtar; Chiara Cerletti; Manuela Livio; Giovanni de Gaetano


Book ID
115775828
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
477 KB
Volume
30
Category
Article
ISSN
0006-2952

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The four stereoisomers of the parent keto acid of the oximino drug ximoprofen have been prepared in high enantiomeric purity. The stereochemistry in the propionic acid chain was established by the combination of Sharpless epoxidation followed by stereoselective hydrogenolysis of the benzylic carbon-