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Indomethacin prevents the long-lasting inhibitory effect of aspirin on human platelet cyclo-oxygenase activity

โœ Scribed by M. Livio; A. Del Maschio; C. Cerletti; G. de Gaetano


Book ID
119049381
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
535 KB
Volume
23
Category
Article
ISSN
0090-6980

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The four stereoisomers of the parent keto acid of the oximino drug ximoprofen have been prepared in high enantiomeric purity. The stereochemistry in the propionic acid chain was established by the combination of Sharpless epoxidation followed by stereoselective hydrogenolysis of the benzylic carbon-