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Sulfur mustard-induced arachidonic acid release is mediated by phospholipase D in human keratinocytes

✍ Scribed by Lee J Lefkowitz; William J Smith


Book ID
117052282
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
264 KB
Volume
295
Category
Article
ISSN
0006-291X

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ATP-induced arachidonic acid (AA) release was studied in [ 3 H]AAprelabeled cultured astrocytes. To characterize the P 2 purinoceptor-mediated effect of ATP, the subtype-specific agonists 2-methylthio ATP (2-MeSATP) and UTP were compared. ATP, UTP, or 2-MeSATP induced a dose-dependent increase of [