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Sulforhodamine GM1-ganglioside: synthesis and physico-chemical properties

✍ Scribed by S. Marchesini; L. Demasi; P. Cestone; A. Preti; V. Agmon; A. Dagan; R. Navon; S. Gatt

Publisher: Elsevier Science
Year: 1994
Tongue: English
Weight: 690 KB
Volume: 72
Category: Article
ISSN: 0009-3084
DOI: 10.1016/0009-3084(94)90098-1

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✦ Synopsis

A fluorescent derivative of GM1-ganglioside was synthesized by linking sulforhodamine 101 to the sphingosine moiety through amino dodecanoyl residue. The product (SR-12GM1) was quantitatively converted to SR-12GM2 by treatment with bovine testes beta-galactosidase and in intact cultured human skin fibroblasts was catabolized to sulforhodamine GM2, GM3 and ceramide; the latter product was further converted to sphingomyelin. In aqueous medium SR-12GM1 formed micelles. When transfer from micelles to vesicles and between vesicles was compared with that of pyrene-GM1, the transfer of SR-12GM1 occurred at higher rates, following in both cases a biexponential curve.

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