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Sulfonamide derivatives of styrylheterocycles as a potent inhibitor of COX-2-mediated prostaglandin E2 production

✍ Scribed by Chaemin Lim; Minhee Lee; Eun-Jung Park; Ran Cho; Hyen-Joo Park; Seong Jin Lee; Heeyeong Cho; Sang Kook Lee; Sanghee Kim

Book ID
104004967
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
357 KB
Volume
20
Category
Article
ISSN
0960-894X

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A series of potent and highly selective cyclooxygenase-2 inhibitors have been prepared by replacing the benzoyl group of indomethacin with a 4-bromobenzyl group, and by extending the acetic acid side chain. These compounds show anti-inflammatory activity in rats with no evidence of GI toxicity, even