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Sulfated polymannuroguluronate, a novel anti-acquired immune deficiency syndrome (AIDS) drug candidate, targeting CD4 in lymphocytes

✍ Scribed by Benchun Miao; Meiyu Geng; Jing Li; Fuchuan Li; Haixia Chen; Huashi Guan; Jian Ding

Book ID: 113487202
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 411 KB
Volume: 68
Category: Article
ISSN: 0006-2952
DOI: 10.1016/j.bcp.2004.04.009

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## Abstract Human immunodeficiency virus (HIV)‐1 infection of the central nervous system occurs in the vast majority of HIV‐infected patients. HIV‐associated dementia (HAD) represents the most severe form of HIV‐related neuropsychiatric impairment. The pathogenesis of HAD is mediated by disruption