Sulfated polymannuroguluronate, a novel anti-acquired immune deficiency syndrome drug candidate, blocks neuroinflammatory signalling by targeting the transactivator of transcription (Tat) protein

Sulfated polymannuroguluronate, a novel

Sulfated polymannuroguluronate, a novel anti-acquired immune deficiency syndrome drug candidate, decreased vulnerability of PC12 cells to human immunodeficiency virus tat protein through attenuating calcium overload

✍ Bin Hui; Jing Li; Mei Yu Geng 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 787 KB

## Abstract Human immunodeficiency virus (HIV)‐1 infection of the central nervous system occurs in the vast majority of HIV‐infected patients. HIV‐associated dementia (HAD) represents the most severe form of HIV‐related neuropsychiatric impairment. The pathogenesis of HAD is mediated by disruption