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Suggestive linkage of chromosome 10p to schizophrenia is not due to transmission ratio distortion

โœ Scribed by Faraone, Stephen V.; Meyer, Joanne; Matise, Tara; Svrakic, Dragun; Pepple, John; Malaspina, Dolores; Suarez, Brian; Hampe, Carol; Chan, Gayan; Aelony, Avram; Friedman, Jill Harkavy; Kaufmann, Charles; Cloninger, C. Robert; Tsuang, Ming T.

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
4 KB
Volume
88
Category
Article
ISSN
0148-7299
DOI
10.1002/(sici)1096-8628(19991215)88:6<607::aid-ajmg6>3.0.co;2-q

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โœฆ Synopsis

The genome scan of the European-American schizophrenia families from the Human Genetics Initiative of the National Institute of Mental Health (NIMH) reported a suggestive linkage to chromosome 10p. Subsequently, Paterson and Petronis [1999] reported evidence for transmission ratio distortion on 10p to females. They suggested that transmission ratio distortion to females might have created spurious evidence for linkage to 10p. To address this issue, we reanalyzed our 10p data using only male-male affected sibling pairs. The two chromosome 10p markers that gave the most evidence for linkage in our prior report continued to show evidence for linkage: D10S1423 (NPL Z = 3.0, P = 0.001) and its neighbor D10S582 (NPL Z = 2.9, P = 0.002). These data suggest that our prior report of suggestive linkage of schizophrenia to markers on 10p cannot be attributed to the transmission ratio distortion to females reported by Paterson and

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