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Lack of evidence for linkage to chromosomes 13 and 8 for schizophrenia and schizoaffective disorder

✍ Scribed by DeLisi, Lynn E.; Shaw, Sarah; Crow, Timothy J.; Shields, Gail; Smith, Angela B.; Larach, Veronica W.; Wellman, Nigel; Loftus, Josephine; Nathankumar, Betsy; Razi, Kamran; Kushner, Maureen; Stewart, John; Vita, Antonio; Comazzi, Margherita; Sherrington, Robin

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 27 KB
Volume: 96
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(20000403)96:2<235::aid-ajmg21>3.0.co;2-l

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✦ Synopsis

A previous report [Blouin et al., 1998: Nat Genet 20:70-73] suggesting linkage to chromosomes 13q32 and 8p21 in families with schizophrenia led us to investigate these regions in a large set of 301 multiplex families with schizophrenia. Multipoint analyses failed to reveal evidence for linkage to any portion of chromosome 13, while only a weakly positive score was present on 8p using the identical marker reported in the earlier report. Failure to confirm the Blouin et al claims in a substantially larger cohort adds emphasis to the inconsistency of the findings concerning linkage in schizophrenia.

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