Suggestive evidence for linkage for restless legs syndrome on chromosome 19p13
✍ Scribed by David Kemlink; Giuseppe Plazzi; Roberto Vetrugno; Federica Provini; Olli Polo; Karin Stiasny-Kolster; Wolfgang Oertel; Sona Nevsimalova; Karel Sonka; Birgit Högl; Birgit Frauscher; Georgios M. Hadjigeorgiou; Peter P. Pramstaller; Peter Lichtner; Thomas Meitinger; Bertram Müller-Myshok; Juliane Winkelmann; Pasquale Montagna
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 306 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1364-6745
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## Abstract Restless legs syndrome (RLS) is a sensory motor disorder characterized by a distressing urge to move the legs and sometimes also other parts of the body usually accompanied by a marked sense of discomfort or pain in the leg or other affected body part. The prevalence of RLS is estimated
## Abstract We describe an autosomal‐dominant locus for Restless Legs Syndrome (RLS) in a French‐Canadian (FC) pedigree. Genome‐wide microsatellite scan and linkage analysis were used in this study. The locus maps to chromosome 16p12.1 and spans 1.18 Mega bases. The maximum multipoint LOD scores ar
## Abstract Restless legs syndrome (RLS) is a common and often misdiagnosed entity among the general population and it may be more common among dialysis patients, with an estimated prevalence of 6.6 to 21.5%. The treatment for uremic RLS has been controversial and therefore a systematic synthesis o