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Sugar-Based Pyrrolidine as a Highly Enantioselective Organocatalyst for Asymmetric Michael Addition of Ketones to Nitrostyrenes

✍ Scribed by Lei Wang; Jie Liu; Tao Miao; Wei Zhou; Pinhua Li; Kai Ren; Xiuli Zhang


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
239 KB
Volume
352
Category
Article
ISSN
1615-4150

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## Abstract A highly diastereoselective and enantioselective Michael addition of cyclohexanone, acetone and other ketones to nitroolefins was developed by the use of an amine organocatalyst based on bispidine. Additionally, a theoretical study of transition structures revealed that this bispidine‐b