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The Use of N-Alkyl-2,2′-bipyrrolidine Derivatives as Organocatalysts for the Asymmetric Michael Addition of Ketones and Aldehydes to Nitroolefins

✍ Scribed by Olivier Andrey; Alexandre Alexakis; Axel Tomassini; Gerald Bernardinelli


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
435 KB
Volume
346
Category
Article
ISSN
1615-4150

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## Abstract A highly diastereoselective and enantioselective Michael addition of cyclohexanone, acetone and other ketones to nitroolefins was developed by the use of an amine organocatalyst based on bispidine. Additionally, a theoretical study of transition structures revealed that this bispidine‐b