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Successful treatment of severe refractory idiopathic thrombocytopenic purpura with liposomal doxorubicin

✍ Scribed by Cosgriff, Thomas M.; Black, Marcus L.; Stein, William

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 13 KB
Volume: 57
Category: Article
ISSN: 0361-8609
DOI: 10.1002/(sici)1096-8652(199801)57:1<85::aid-ajh16>3.0.co;2-8

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✦ Synopsis

Idiopathic thrombocytopenic purpura (ITP) is refractory to initial treatment (steroids and splenectomy) in 25 to 30% of patients. These patients have a significant risk of fatal hemorrhage. Two patients with ITP refractory to multiple interventions and severe depression of platelet counts responded to treatment with liposomal doxorubicin with a return of platelet counts to normal. The drug is easily administered and was well tolerated. Use of this drug in refractory ITP merits further study.

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