Successful treatment of cutaneous Langerhans cell histiocytosis with low-dose methotrexate
β Scribed by A.E. Steen; K.H. Steen; R. Bauer; T. Bieber
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 384 KB
- Volume
- 145
- Category
- Article
- ISSN
- 0007-0963
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π SIMILAR VOLUMES
Six children received etoposide as the single agent for treatment of Langerhans cell histiocytosis (LCH; histiocytosis X). Five were less than 2 years old at diagnosis. All had multiorgan involvement; one had liver and pulmonary dysfunction. Two infants also had clinical signs of immune deficiency.
Viana et al. [I] described their experience with etoposide (VP-16) as initial therapy in the management of patients with Langerhans cell histiocytosis (LCH). However, caution should be used in advocating the use of an epipodophyllotoxin as the "drug of choice" for the treatment of this disorder. Alt