Substrate specificity in enzymatically mediated trans acetylation reactions of calicheamicinone intermediates

Enzymatic alkoxycarbonylation reactions

Enzymatic alkoxycarbonylation reactions on the intermediate in the synthesis of (−)-paroxetine, trans-N-benzyloxycarbonyl-4-(4′-fluorophenyl)-3-hydroxymethylpiperidine

✍ Gonzalo de Gonzalo; Rosario Brieva; Vı́ctor M. Sánchez; Miguel Bayod; Vicente Go 📂 Article 📅 2003 🏛 Elsevier Science 🌐 English ⚖ 201 KB

Several enzymatic alkoxycarbonylation processes are evaluated for the resolution of trans-N-benzyloxycarbonyl-4-(4%fluorophenyl)-3-hydroxymethylpiperidine, a chiral intermediate in the synthesis of (-)-paroxetine. Candida antarctica lipase B (CAL-B) catalyzes the enzymatic alkoxycarbonylation with d