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Enzymatic alkoxycarbonylation reactions on the intermediate in the synthesis of (−)-paroxetine, trans-N-benzyloxycarbonyl-4-(4′-fluorophenyl)-3-hydroxymethylpiperidine

✍ Scribed by Gonzalo de Gonzalo; Rosario Brieva; Vı́ctor M. Sánchez; Miguel Bayod; Vicente Gotor

Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
201 KB
Volume
14
Category
Article
ISSN
0957-4166

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✦ Synopsis

Several enzymatic alkoxycarbonylation processes are evaluated for the resolution of trans-N-benzyloxycarbonyl-4-(4%fluorophenyl)-3-hydroxymethylpiperidine, a chiral intermediate in the synthesis of (-)-paroxetine. Candida antarctica lipase B (CAL-B) catalyzes the enzymatic alkoxycarbonylation with diallylcarbonate with high enantioselectivity.

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