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Substrate Enantioselective and Product Stereoselective Metabolism of Racemic 2-Hydroxy-3-methylcholanthrene by Rat Liver Microsomes

โœ Scribed by Shou, Magang; Yang, Shen K.

Book ID
126623056
Publisher
Taylor and Francis Group
Year
1996
Tongue
English
Weight
442 KB
Volume
10
Category
Article
ISSN
1040-6638

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Metabolism of halazepam by rat liver mic
Metabolism of halazepam by rat liver microsomes: Stereoselective formation and n-dealkylation of 3-hydroxyhalazepam
โœ Xiang-Lin Lu; Shen K. Yang ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 822 KB

Metabolism of halazepam [7-chloro-1,3-dihydro-5-phenyl-l-(2,2,2-trifluoroethyl)-W-l,4-benzodiazepin-2-one, HZ] was studied by incubation with liver microsomes prepared from untreated, phenobarbital (PB)-treated, and 3-methylcholanthrene (3MC)-treated male Sprague-Dawley rats. Metabolites of HZ were