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Metabolism of benzo[a]pyrene: Effect of substrate concentration and 3-methylcholanthrene pretreatment on hepatic metabolism by microsomes from rats and mice

✍ Scribed by G.M. Holder; H. Yagi; D.M. Jerina; W. Levin; A.Y.H. Lu; A.H. Conney

Book ID: 115702486
Publisher: Elsevier Science
Year: 1975
Tongue: English
Weight: 836 KB
Volume: 170
Category: Article
ISSN: 0003-9861
DOI: 10.1016/0003-9861(75)90151-4

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## Abstract The metabolism of benzo[a]pyrene (BP)^4^by cultured tracheobronchial tissues from different species ‐ human, bovine, hamster, rat and mouse ‐ has been investigated. The total metabolism, as measured by both organic solvent‐extractable and water‐soluble metabolites of BP, was substantial