Substrate-Directed Diastereoselective Hydroformylation of Methallylic Alcohols

✍ Scribed by Dr. Bernhard Breit

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 383 KB
• Volume: 35
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.199628351

✦ Synopsis

dropwise to a suspension of [AuCl(tht)] (100 mg. 0.312 mmol) in acetone (10 mL). The reaction mixture was stirred for 5 h and the solvents were evaporated to dryness. Addition of hexane (10 mL) and filtration through Kieselguhr led to a colorless solution Concentration of the solution to ahout 1 mL and addition of a mixture of ether (I mL) and methanol (10 mL) gave a white solid which was separated by filtration. washed uith methanol, and dried under vacuum. Compound C1 was purified by column chromatography (hexane/dichloromethane 4/1) to give a white microcrystalline product.